Table 4.
Univariate and multivariable analysis of factors associated with overall survival in bladder cancer patients who underwent radical cystectomy including HALPA.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender (female vs. male) | 0.794(0.528–1.193) | 0.264 | ||
| Age (>65 vs. ≤65) | 2.220(1.592–3.098) | 0.001 | 1.849 (1.294–2.641) | 0.001 |
| Smoking history | 1.014(0.725–1.417) | 0.937 | ||
| Alcohol-drinking history | 0.922(0.565–1.504) | 0.743 | ||
| Hypertension | 1.130(0.803–1.591) | 0.480 | ||
| Histology type (TCC vs. no-TCC) | 0.706(0.331)1.506 | 0.363 | ||
| G (3 vs. 2) | 2.118(1.373–3.267) | <0.001 | ||
| T (MIBC vs. NMIBC) | 4.301(2.665–6.942) | <0.001 | 2.831 (1.720–4.658) | <0.001 |
| N (positive vs. negative) | 2.448(1.716–3.491) | <0.001 | 2.135 (1.448–3.146) | <0.001 |
| M (positive vs. negative) | 10.509(3.842–28.746) | <0.001 | 3.807 (1.278–11.336) | 0.016 |
| Adjunctive chemotherapy | 2.056(1.437–2.941) | <0.001 | ||
| ASA (3&4 vs. 1&2) | 2.068(1.442–2.964) | <0.001 | ||
| Hypoalbuminemia | 2.919(1.900–4.484) | <0.001 | ||
| Anemia | 2.433(1.775–3.335) | <0.001 | ||
| PLR | 1.963(1.421–2.712) | <0.001 | ||
| HALP | 2.820(1.976–4.025) | <0.001 | ||
| HALPA | <0.001 | <0.001 | ||
| 0 | 1 | 1 | ||
| 1 | 2.084(1.477–2.941) | <0.001 | 1.624 (1.139–2.314) | 0.007 |
| 2 | 6.300(3.628–10.940) | <0.001 | 3.471 (1.861–6.472) | <0.001 |
TCC, transitional cell carcinoma; MIBC, muscle-invasive bladder cancer; NMIBC, non-muscle invasive bladder cancer; ASA, American Society of Anesthesiologists; PLR: platelet to lymphocyte ratio; HR, hazard ratio; CI: confidence interval.