Fig. 5.
GSMR vs. conditional GSMR. Shown are the results from the GSMR analyses compared with those from the conditional GSMR analyses. In the conditional GSMR analysis, the effect size of each risk factor on disease was estimated conditioning on the other risk factors (see Methods for details of the conditional method). “Community”: disease GWAS data from a meta-analysis of the two community-based studies. “Case–control”: disease GWAS data from independent published case–control studies. In gray are the associations that do not pass the P-value threshold 2.2 × 10−4 in the conditional analysis