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. 2018 Jan 15;8:769. doi: 10.1038/s41598-017-19067-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Momentary state ratings during a 239-day anti-depressant reduction experiment. The experimental phases are indicated by the varying background shading. The detected correlation change points (indicated by the dashed lines) provide some evidence supporting the critical slowing down phenomenon before a sudden critical transition, which was the depression relapse observed on Day 127 (indicated by the black vertical line).