Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 15;9:188. doi: 10.1038/s41467-017-02526-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Epigenetic modifications only correlate with higher-order folding of the TADs but not the folding of individual TADs. a The TADs could be classified into four major types according to the enrichment of 15 histone modifications and non-histone chromosomal proteins within each TAD (Supplementary Methods). Shown is an example of the distribution of these types with active (orange bar below the heatmap), inactive (blue bar), polycomb (green bar), and undetermined (gray bar) chromatin within the TADs in a 380 kb region of chr3R. Inset: the extent of DNA condensation within the TADs, as determined from the average of contact frequencies between loci within the TAD. b Comparison of the frequency with which active or inactive TADs tend to interact with their immediately neighboring TADs. The upper heatmap shows the positions of the TADs, while the lower heatmap shows the significance of the observed contacts, with those colored red (blue) exhibiting much greater (lower) interaction strength than expected by chance (Methods) in a 530 kb region of chr2R. c The relative interaction strength (as shown in b) between pairs of TADs. A active, I inactive, P polycomb