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. 2018 Jan 15;8:742. doi: 10.1038/s41598-017-18757-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential expression of Wnt signaling pathway genes after spinal cord injury. (a,b) Canonical and non-canonical Wnt signaling pathways are shown. Genes that were differentially expressed at least once during the experimental time course are indicated in red (up) or blue (down) regulated. Heat maps showing expression of genes that were differentially expressed at least once during the experimental time course for spinal cord and brain. Left panels show raw expression data and right panels show log₂-fold changes (FC) relative to the uninjured state. TPM = transcripts per million reads. Lamprey gene IDs and corresponding gene symbols are found in Supplementary Table S2. (c) KEGG analysis of the Wnt signaling pathways showing transcripts identified as differentially expressed in spinal cord (orange), brain (purple) or both (blue). KEGG pathway map 04310 is adapted here from http://www.kegg.jp/kegg/kegg1.html. The KEGG database has been described previously^93–95.