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. 2018 Jan 15;8:767. doi: 10.1038/s41598-017-19095-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two docking structures of dual cross-linked Pt3-GQ complex (A: conf1; B: conf2). Pt3 and G₂/G₁₉ were shown in Licorice model (Pt: brown; N: blue; C: cyan; Cl: red; G₂: orange; G₁₉: purple), and the rest G-quadruplex was shown in ribbon model (T: pink; A: gray; G: green; G₂: orange; G₁₉: purple). (C) The hydrogen bond formed between 3′-A₂₂A₂₁T₂₀ trinucleotides and top G-tetrad (G triad in cyan(C)/blue(N)/red(O); 3′-trinucelotides in green(C)/violet(N)/pink(O)).