Fig. 1.

Landscape of clonal and subclonal mutations in Asian EGFR-mutant tumors. a Phylogenetic trees generated for the 16 Asian EGFR-mutant LUADs. Trunks, branches and tips are depicted in blue, green, and red, respectively, while non-silent mutations carrying LUAD specific drivers are in red and other cancer drivers are in blue (Methods section). All patients are never-smokers except A103 (marked *) who was a light ex-smoker. Truncal mutation burden followed by total mutation burden for all sectors is indicated below the trees. b Bar plot representing truncal and non-truncal mutation burden per sector. c Oncoprint heatmap for mutations in LUAD drivers depicting the presence (see color legend) or absence (gray box) and type of non-silent mutation. d Proportions of the three mutation signatures identified for each sector. Signature numbers are according to the COSMIC nomenclature. e Pie charts representing contribution of the three mutation signatures in early (trunk) and late (branch/private) mutations