Fig. 2.

Genomic instability and variegated copy number landscape of EGFR-mutant tumors. a Bar plot representing the fraction of genome altered by copy number alterations relative to ploidy of the sector, which is termed as the genomic instability index (GII). b Bar showing genome doubling status. Blue indicates significant evidence for genome doubling (Supplementary Data 3, Methods section) and gray indicates no genome doubling. c Heatmap depicting gains in known driver or recurrently amplified cytobands in LUAD (Methods section). Light red represents gain in one copy beyond the ploidy while dark red represents gain in ≥2 copies beyond the ploidy. d Heatmap depicting losses in known driver or recurrently amplified cytobands in LUAD (Methods section). Light blue represents loss of one copy relative to the ploidy while dark blue represents loss of ≥2 copies beyond the ploidy. Samples for all panels are as depicted in d. TP53 wild-type samples are depicted in gray