Fig. 3.

EGFR is a dominant driver with few co-drivers. Dot plots comparing mutation burden on a trunk and b branches between the Asian EGFR-mutant and smoker dominated Caucasian cohorts^{19, 20}. c Dot plot comparing number of branch/private mutated drivers (extended driver list) between the EGFR-mutant and smoker dominated Caucasian cohorts^{19, 20}. Welch’s t-test was used to compare the two groups. d Dot plot showing that EGFR-mutant LUADs have significantly fewer truncal drivers (extended driver list; Welch’s t-test) compared to smoker Caucasian LUADs. Three random sectors were picked 20 times iteratively and averages of the iterations are represented as circles in a–d. Horizontal line indicates the median for that cohort. e “Driver dominance score” measuring driver self-sufficiency for each of 78 LUAD driver genes calculated across published 412 tumors^{3, 4} is plotted against the fraction of patients carrying the mutated driver