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. 2018 Jan 15;9:222. doi: 10.1038/s41467-017-02595-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — High expression of AICDA in DLBCL causes higher DNA methylation heterogeneity and hypomethylation. a Density plot showing the inter-tumor pairwise methylation distance between ERRBS profiles of AICDA-low and AICDA-high DLBCL. AICDA-high DLBCL have greater pairwise distance, indicating increased inter-tumor heterogeneity; two-sided Wilcoxon's signed-rank test. b–d Scatterplots showing shift in mean methylation (b), inter-tumor diversity (c), and intra-tumor heterogeneity (d) of DLBCL AICDA perturbation signature between AICDA-low and AICDA-high DLBCL. e Bar plot showing the distribution of DLBCL AICDA-perturbed CpGs relative to the distribution of all represented CpGs; Fisher’s exact test. f Bar plot showing the relative distribution of DLBCL AICDA-perturbed CpGs within proximity to CpG islands; Fisher’s exact test. g Venn diagram showing the overlap between genes significantly over-representing DLBCL AICDA signature CpGs and murine orthologs over-representing VavP-Bcl2+Aicda signature CpGs; hypergeometric test. h Bar plot showing the relative fraction of DLBCL subtypes within AICDA-high and AICDA-low DLBCL cases (*P < 0.05, **P < 0.01, ***P < 0.001)