Table 4.
Genetic risk for early AMD according to sex.
| Genotype | Prevalence (%) | Men | Prevalence (%) | Women | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control, n = 1236 | Early AMD, n = 174 | Control, n = 1548 | Early AMD, n = 181 | |||||||
| No. (%) | No. (%) | Odds (95% CI) | P-value | No. (%) | No. (%) | Odds (95% CI) | P-value | |||
| rs10490924/ARMS2 | ||||||||||
| GG | 10.7 | 500 (40.5) | 60 (34.5) | 1 (reference) | 7.4 | 604 (39.0) | 48 (26.5) | 1 (reference) | ||
| TG | 12.6 | 589 (47.7) | 85 (48.8) | 1.21 (0.85–1.72) | 0.716 | 10.0 | 753 (48.6) | 84 (46.4) | 1.38 (0.95–2.01) | 0.0979 |
| TT | 16.5 | 147 (11.9) | 29 (16.7) | 1.65 (1.02–2.69) | 0.069 | 20.4 | 191 (12.3) | 49 (27.1) | 3.25 (2.10–5.04) | <0.0001 |
| rs800292/CFH I62V | ||||||||||
| CC | 9.9 | 456 (36.9) | 50 (28.7) | 1 (reference) | 8.5 | 559 (36.1) | 52 (28.7) | 1 (reference) | ||
| CT | 13.8 | 582 (47.1) | 93 (53.5) | 1.45 (1.01–2.1) | 0.2425 | 9.8 | 760 (49.1) | 83 (45.9) | 1.12 (0.77–1.61) | 0.126 |
| TT | 13.5 | 198 (16.0) | 31 (17.8) | 1.43 (0.88–2.32) | 0.4299 | 16.7 | 229 (14.8) | 46 (25.4) | 2.04 (1.33–3.14) | 0.0005 |
Adjusted for age; Significant values are in bold.