Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 15;8:792. doi: 10.1038/s41598-017-18775-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Titin isoform content in an animal in each of the three weight categories. (a) Gels showing titin isoform staining using SYPRO Ruby protein staining. Each example is from a different gel and gels are cropped. (Full length gels are included in Supplementary Information S4). The grayscale of the 75–150 kg-group gel is adjusted to generate equal appearance of the three gels. (b) Bar graph showing titin ratio (N2BA/N2B isoform). Ratio is decreased in the highest weight category, indicating a shift from the compliant N2BA titin isoform towards the stiff N2B titin isoform. Measured in a subset within each group (n = 7, n = 7 and n = 4, respectively, for each group); Data are presented as individual animal data points and as mean ± s.e.m.; *P < 0.05 vs < 75 kg-group; ^†P < 0.05 vs 75–150 kg-group (by One-Way ANOVA followed by SNK post-hoc testing).