Table 2.
Univariate analysis of prognostic factors regarding progression-free and overall survival.
| Prognostic factor | No. of patients | Progression free survival | Overall survival | ||||
|---|---|---|---|---|---|---|---|
| Median (m) | 5/10-year (%) | p-value | Median (m) | 5/10-year (%) | p-value | ||
| Age (y) | 0.112 | 0.299 | |||||
| ≤50 | 55 | 143 | 64.7/59.7 | 158 | 69.9/58.9 | ||
| >50 | 18 | 50 | 45.8/45.8 | 50 | 49.7/49.7 | ||
| Sex | 0.245 | 0.416 | |||||
| Male | 39 | 143 | 51.9/51.9 | 158 | 61.4/52.9 | ||
| Female | 34 | 130 | 69.9/62.1 | NR | 69.4/60.3 | ||
| Preoperative KPS | 0.617 | 0.951 | |||||
| 90–100 | 21 | NR | 64.3/64.3 | NR | 64.3/64.3 | ||
| 70–80 | 52 | 130 | 58.7/53.6 | 158 | 65.9/55.3 | ||
| 1p/19q status | <0.001 | <0.001 | |||||
| Codeletion present | 32 | NR | 87.5/87.5 | NR | 90.0/90.0 | ||
| Codeletion absent | 41 | 42 | 40.8/35.4 | 55 | 47.7/35.1 | ||
| IDH1 status | <0.001 | 0.001 | |||||
| Mutated | 36 | NR | 79.4/74.5 | NR | 83.9/74.6 | ||
| Wild type | 37 | 40 | 42.1/38.8 | 50 | 47.5/40.4 | ||
| 2016 WHO classification | 0.001 | 0.001 | |||||
| AO, IDH-mutant and 1p/19q-codeleted | 25 | NR | 88.0/88.0 | NR | 91.2/91.2 | ||
| AA, IDH-mutant | 11 | NR | 63.6/53.0 | NR | 71.6/51.1 | ||
| AA, IDH-wildtype | 37 | 40 | 42.1/38.8 | 50 | 47.5/40.4 | ||
| MGMT promoter status | 0.002 | <0.001 | |||||
| Methylated | 49 | NR | 71.0/71.0 | NR | 73.9/73.9 | ||
| Unmethylated | 24 | 45 | 38.3/27.3 | 50 | 48.1/26.7 | ||
| Extent of resection | <0.001 | 0.007 | |||||
| Gross total resection | 43 | 143 | 76.5/69.2 | 158 | 78.2/69.8 | ||
| Subtotal resection | 18 | NR | 55.0/55.0 | NR | 60.2/52.7 | ||
| Partial resection-biopsy | 12 | 28 | 16.7/16.7 | 49 | 41.7/20.8 | ||
| Chemotherapy | 0.970 | 0.701 | |||||
| Yes | 45 | 143 | 58.6/55.7 | 158 | 65.3/56.3 | ||
| No | 28 | 130 | 63.0/56.0 | NR | 65.1/54.3 | ||
KPS, Karnofsky Performance Status; Dx, diagnosis; WHO, World Health Organization; IDH, isocitrate dehydrogenase gene; AO, Anaplastic Oligodendroglioma; AA, Anaplastic Astrocytoma; MGMT, O6-methylguanine-DNA-methyltransferase gene; NR, not reached.