Table 3.
Multivariate analysis of prognostic factors for progression-free and overall survival.
| Variable | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| 2016 WHO classification | ||||
| AO, IDH-mutant and 1p/19q-codeleted | Reference | Reference | ||
| AA, IDH-mutant | 2.674 (0.618–11.580) | 0.188 | 4.290 (0.816–22.558) | 0.085 |
| AA, IDH-wildtype | 5.725 (1.688–19.412) | 0.005 | 8.252 (1.919–35.484) | 0.005 |
| Extent of resection | ||||
| GTR-STR | Reference | Reference | ||
| PR-Bx | 3.017 (1.411–6.452) | 0.004 | 2.405 (1.079–5.363) | 0.032 |
WHO, World Health Organization; AO, Anaplastic Oligodendroglioma; IDH, isocitrate dehydrogenase gene; AA, Anaplastic Astrocytoma; GTR, Gross Total Resection; STR, Subtotal Resection; PR, Partial Resection; Bx, Biopsy; PFS, Progression Free Survival; OS, Overall Survival; HR, Hazard Ratio; CI, Confidence Interval.