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. 2018 Jan 15;8:743. doi: 10.1038/s41598-017-16927-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of exogenous MIF increases and ISO-1 inhibits the BBB permeability following tMCAO in rats. Evans blue dye was used to evaluate the BBB permeability in vivo. (A) The time-course of BBB permeability assay. (B) Representative images of Evans blue dye in brain tissue. Note that Evans blue dye increased in ipsilateral cortex following tMCAo. MIF increased and ISO-1 inhibited stroke-induced increase of BBB permeability. (C) The summarized results of dye content in the cortex tissue. (D) The expressions of GFAP and tight junction proteins occludin, claudin-5 and ZO-1 in brain tissue (full-length blots are presented in Supplementary Figure 1). Data are presented as mean ± S.E.M. (n = 4–6 in Evans blue assay, and n = 5 in Western blotting). *p < 0.05 compared with contralateral cortex. ^#p < 0.05 compared with control group.