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. 2018 Jan 15;8:725. doi: 10.1038/s41598-017-18981-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SPARC expression in patients with NAFLD induced liver injury. (A) Expression of SPARC was observed on protein (immunohistochemistry) in patients with NAFLD. Magnification 100× and 400×. Patients with high hepatic SPARC mRNA expression had significantly higher serum M30 levels (B) and nominally higher RIPK3 mRNA expression (C). Data are mean ± sem, *p < 0.05. Comparison between groups was performed with Mann-Whitney U Test. mRNA expressions of SPARC and RIPK3 were significantly correlated (D). Spearman rank test.