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. 2018 Jan 15;8:725. doi: 10.1038/s41598-017-18981-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pro-fibrogenic gene expression is increased in patients with NAFLD and high SPARC expression. NAFLD patients were grouped by hepatic SPARC mRNA expression. Patients with high SPARC expression had significantly higher collagen 1 alpha (A) and TGF-beta (B) mRNA expression in the liver. Data are mean ± sem, *p < 0.05. Comparison between groups was performed with Mann-Whitney U Test. mRNA expressions of both pro-fibronic genes were significantly correlated to SPARC expression (C,D). Spearman rank Test.