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. 2018 Jan 14;24(2):195–210. doi: 10.3748/wjg.v24.i2.195

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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INT-767 treatment for 8 wk reduces hepatic collagen deposition in ob/ob-NASH mice with biopsy-confirmed liver pathology. A: Collagen 1a1 (immunohistochemistry); B: Fractional area of collagen (immunohistochemistry); C: Label free SHG/2-PE images for collagen fiber deposition (green) in hepatic parenchyma (red). Data are expressed as % of total parenchymal area (subtraction of fat area); D: Fractional area of collagen fiber, collagen fiber density, and collagen fiber reticulation index (SHG analysis). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 (unpaired t-test).