Skip to main content

View full-text article in PMC

. 2018 Jan 14;24(2):195–210. doi: 10.3748/wjg.v24.i2.195

Table 3.

INT-767 and obeticholic acid improve quantitative liver histopathology in ob/ob-NASH mice

Treatment	Lipid (steatosis)		Galectin-3 (inflammation)		Collagen 1a1 (fibrosis)
Treatment	% fractional area
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Vehicle (n = 11)	33.0 ± 0.9	30.4 ± 0.9	5.7 ± 0.5	7.8 ± 0.5	1.2 ± 0.3	12.1 ± 0.4
OCA 10 mg/kg (n = 12)	33.4 ± 0.8	31.8 ± 0.4	5.5 ± 0.3	5.0 ± 0.2^a	0.9 ± 0.1	9.0 ± 0.6^a
OCA 30 mg/kg (n = 11)	32.2 ± 1.1	22.7 ± 1.0^a	5.5 ± 0.4	4.0 ± 0.4^a	1.2 ± 0.2	8.0 ± 0.7^a
INT-767 3.0 mg/kg (n = 12)	33.0 ± 0.9	29.4 ± 1.3^a	5.6 ± 0.5	5.4 ± 0.2^a	1.2 ± 0.2	8.5 ± 0.6^a
INT-767 10 mg/kg (n = 11)	33.7 ± 0.8	12.5 ± 1.5^a	5.6 ± 0.3	2.9 ± 0.1^a	0.9 ± 0.2	5.0 ± 0.3^a

Fractional area (mean ± SE) at the end of study;

^a

P <0.05 vs vehicle (two-way ANOVA, Bonferroni’s post-hoc test).