Table 3.
Allele and genotype frequencies of IRF5 rs77416878C/T and rs2280714T/C in Vietnamese patients with hepatitis B virus-related liver diseases n (%)
| IRF5 variants | HC, n = 242 | CHB, n = 99 | LC, n = 131 | HCC, n = 149 |
| rs77416878 | ||||
| CC | 192 (79.4) | 79 (79.8) | 98 (74.8) | 115 (77.2) |
| CT | 48 (19.8) | 19 (19.2) | 32 (24.4) | 31 (20.8) |
| TT | 2 (0.8) | 1 (1) | 1 (0.8) | 3 (2) |
| Allele | ||||
| C | 432 (89.3) | 177 (89.4) | 228 (87) | 261 (87.6) |
| T | 52 (10.7) | 21 (10.6) | 34 (13) | 37 (12.4) |
| Dominant | ||||
| CC | 192 (79.4) | 79 (79.8) | 98 (74.8) | 115 (77.2) |
| CT + TT | 50 (20.6) | 20 (20.2) | 33 (24.4) | 34 (22.8) |
| Recessive | ||||
| CC + CT | 240 (99.2) | 98 (99) | 130 (99.2) | 146 (98) |
| TT | 2 (0.8) | 1 (1) | 1 (0.8) | 3 (2) |
| rs2280714 | ||||
| TT | 84 (34.7) | 31 (31.3) | 47 (35.9) | 39 (26.2) |
| TC | 114 (47.1) | 52 (52.5) | 69 (52.7) | 87 (58.4) |
| CC | 44 (18.2) | 16 (16.2) | 15 (11.4) | 23 (15.4) |
| Allele | ||||
| T | 282 (58.3) | 114 (57.6) | 163 (62.2) | 165 (55.4) |
| C | 202 (41.7) | 84 (42.4) | 99 (37.8) | 133 (44.6) |
| Dominant | ||||
| TT | 84 (34.7) | 31 (31.3) | 47 (35.9) | 39 (26.2) |
| TC + TT | 158 (65.3) | 78 (68.7) | 84 (64.1) | 110 (73.8) |
| Recessive | ||||
| TT + TC | 198 (81.8) | 83 (83.8) | 116 (88.6) | 126 (84.6) |
| CC | 44 (18.2) | 16 (16.2) | 15 (11.4) | 23 (15.4) |
HC: Healthy controls; CHB: Chronic hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma. All comparisons between groups using binary logistic model adjusted for age and gen did not indicate a significant difference (adjusted P > 0.05, data not shown in this table).