Table 4.
Haplotype distribution among chronic hepatitis B virus carriers and the association of IRF5 haplotypes with hepatitis B virus-infected liver diseases n (%)
| Haplotypes | HC, n = 484 | CHB, n = 198 | LC, n = 298 | HCC, n = 262 |
LC vs CHB |
HCC vs CHB |
HCC vs LC |
|||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95%CI) | P value | |||||
| ACAC | 196 (40.6) | 83 (41.9) | 98 (37.4) | 132 (44.3) | Reference | Reference | Reference | |||
| TCGT | 141 (29.0) | 37 (18.7) | 86 (32.7) | 81 (27.2) | 2.1 (1.2-3.3) | 0.008 | NS | 0.7 (0.4-1.1) | 0.08 | |
| TCAT | 33 (6.8) | 27 (13.6) | 12 (4.6) | 13 (4.4) | 0.4 (0.2-0.8) | 0.037 | 0.3 (0.15-0.7) | 0.003 | NS | |
| ACAT | 54 (11.2) | 24 (12) | 30 (11.5) | 31 (10.4) | NS | NS | NS | |||
| TTAT | 49 (10.2) | 18 (9.1) | 34 (13) | 33 (11.1) | NS | NS | NS | |||
| ACGC | 2 (0.4) | 1 (0.5) | 0 (0) | 1 (0.3) | NS | NS | NS | |||
| ACGT | 5 (1) | 5 (2.5) | 1 (0.4) | 3 (1) | NS | NS | NS | |||
| TCGC | 2 (0.4) | 0 (0) | 1 (0.4) | 0 (0) | NS | NS | NS | |||
| TTGT | 2 (0.4) | 3 (1.5) | 0 (0) | 4 (1.3) | NS | NS | NS | |||
HCC: Hepatocellular carcinoma. Comparison between HC vs HBV patient group did not indicate any significant difference (data not shown in this table). OR and P values were calculated by using binary logistic model adjusted for age and gender, CHB: Chronic hepatitis B; LC: Liver cirrhosis.