Figure 7.

p38α Regulates the Expression of Genes Implicated in Tumor-Initiating Cell Maintenance and Tumorigenesis

(A) GSEA plots showing a negative correlation between the genetic signature of p38α null luminal cells isolated from pre-neoplastic lesions and published signatures of luminal progenitor cells from PyMT-induced tumors (Lim et al., 2010). Ranked list ordered according to fold changes in the p38α null luminal tumor cells. Hits correspond to the position of genes from the published signatures.

(B) Genes known to play a role in TICs and tumor progression were analyzed by qRT-PCR in luminal cells isolated from mammary pre-neoplastic lesions of mice with the indicated genotypes (n = 3 independent experiments). Values refer the expression level of each gene in cells from MMTV-Cre;PyMT mice, which was given the value of 1. ^∗p ≤ 0.05; ^∗∗p ≤ 0.005; ^∗∗∗p ≤ 0.0005; ^∗∗∗∗p ≤ 0.00005.