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. 2017 Dec 7;10:408. doi: 10.3389/fnmol.2017.00408

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Copyright © 2017 Kinboshi, Mukai, Nagao, Matsuba, Tsuji, Tanaka, Tokudome, Shimizu, Ito, Ikeda, Inanobe, Kurachi, Inoue and Ohno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of fluoxetine on BDNF expression in astrocytes. (A) Effects of fluoxetine on BDNF mRNA expression. Astrocytes were treated with the indicated concentrations of fluoxetine (1–30 μM) and BDNF mRNA expression was analyzed by quantitative reverse transcription (RT)-PCR. (B) Effects of fluoxetine on BDNF protein expression. Astrocytes treated with 30 μM fluoxetine for 24 h and the BDNF protein levels were analyzed by ELISA. The BDNF mRNA levels are expressed as the ratio to GAPDH mRNA. Each point represents the mean ± SEM of 5–6 separate experiments. ^∗P < 0.05, ^∗∗P < 0.01, significantly different from the astrocytes treated with vehicle.