Table 3.

Discriminatory accuracy of traditional risk factors and of biomarkers for identifying individuals with and without coronary heart disease. Values are area under the receiver operating characteristic (AUC) curve and 95% confidence intervals (CI) as well as the True Positive Fraction (TPF) for a False Positive Fraction (FNF) of 5% (TPF_{FPF 5%}).

	AUC (95% CI)		TPFFPF5%
		Difference
Age	0.63 (0.60–0.65)	-0.05	0.08 (0.06–0.10)
Sex	0.61 (0.59–0.64)	-0.07	–a
Age and sex	0.68 (0.66–0.70)	Reference	0.09 (0.07–0.13)
Traditional risk factors
– Systolic blood pressurea	0.65 (0.62–0.67)	-0.03	0.10 (0.08–0.14)
– Diastolic blood pressure	0.60 (0.58–0.62)	-0.08	0.08 (0.05–0.10)
– Hypertension arterial	0.58 (0.56–0.61)	-0.10	–
– Glucose	0.61 (0.59–0.64)	-0.07	0.14 (0.10–0.17)
– Diabetes	0.57 (0.54–0.59)	-0.11	–
– Total cholesterol	0.57 (0.54–0.59)	-0.11	0.06 (0.04–0.08)
– HDL cholesterol	0.64 (0.61–0.66)	-0.04	0.02 (0.01–0.04)
– LDL cholesterol	0.58 (0.55–0.61)	-0.10	0.07 (0.04–0.09)
– LDL/HDL ratio	0.65 (0.63–0.68)	-0.03	0.11 (0.09–0.17)
– Triglycerides	0.61 (0.58–0.63)	-0.07	0.09 (0.07–0.12)
– Body Mass Index (BMI)	0.59 (0.56–0.61)	-0.09	0.07 (0.05–0.10)
– Cigarette smoking	0.58 (0.55–0.60)	-0.14	–
Biomarkers
– CRP	0.61 (0.58–0.63)	-0.07	0.09 (0.06–0.11)
– Cystatin C	0.62 (0.59–0.65)	-0.06	0.11 (0.08–0.14)
– Lp-PLA2 activity	0.61 (0.58–0.64)	-0.07	0.11 (0.07–0.14)
– N-BNP	0.54 (0.51–0.57)	-0.14	0.10 (0.07–0.12)
– N-BNP (309 pg/mL)	0.52 (0.49–0.55)	-0.16	–
Combinations
– Traditional risk factors (RF)	0.71 (0.69–0.74)	0.03	0.19 (0.16–0.23)
– Biomarkers (BM)	0.67 (0.64–0.69)	-0.01	0.13 (0.10–0.17)
– RF and BM	0.74 (0.71–0.76)	0.06	0.21 (0.17–0.26)
– Age, sex and RF	0.75 (0.73–0.77)	0.07	0.22 (0.18–0.27)
– Age, sex and BM	0.72 (0.69–0.74)	0.04	0.16 (0.11–0.20)
– Age, sex, RF and BM	0.77 (0.74–0.79)	0.08	0.23 (0.17–0.28)

CRP: C-Reactive Protein. LpPLA₂: Lipoprotein-associated phospholipase A2. NTBNP: N-terminal B-type natriuretic peptide.

^aValue not calculated as the variable is dichotomous.