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. 2017 Oct 30;15(1):576–584. doi: 10.3892/etm.2017.5400

Figure 5.

Figure 5.

RSV regulates SOD and MDA mRNA levels via SIRT1 in INS-1E cells. The relative expression of (A) SOD and (B) MDA was normalized to β-actin in PA-induced INS-1E cells. **P<0.01. RSV, resveratrol; SOD, superoxide dismutase; MDA, malondialdehyde; SIRT1, Sirtuin 1; INS-1E, insulinoma cell line clone 1E; NC, normal INS-1E cells pretreated with vehicle; HF, INS-1E cells incubated with 30 mM PA for 24 h; HF+RSV, INS-1E cells incubated with 30 mM PA and 10 µm RSV for 24 h; HF+RSV+SIRT siRNA, INS-1E cells transfected with SIRT1 siRNA for 48 h and incubated with PA 30 mM and 10 µm RSV for 24 h; HF+RSV+NC siRNA, INS-1E cells transfected with negative control siRNA for 48 h and incubated with PA 30 mM and 10 µm RSV for 24 h; siRNA, small interfering RNA.