Table IV.
Clinicopathological features and their correlations with degree of SLX staining at the invasive front.
| Degree of SLX staining, no. (%) | ||||
|---|---|---|---|---|
| Characteristic | Total (n=209) | High expression (n=44) | Low expression (n=165) | P-value |
| Age, years | ||||
| <70 | 128 | 31 (24) | 97 (76) | 0.15 |
| ≥70 | 81 | 13 (16) | 68 (84) | |
| Sex | ||||
| Male | 125 | 27 (22) | 98 (78) | 0.81 |
| Female | 84 | 17 (20) | 67 (80) | |
| Tumor location | ||||
| Colon | 152 | 29 (19) | 123 (81) | 0.25 |
| Rectum | 57 | 15 (26) | 42 (74) | |
| Tumor size | ||||
| <45 mm | 86 | 20 (23) | 66 (77) | 0.51 |
| ≥45 mm | 123 | 24 (20) | 99 (80) | |
| Depth of tumor invasion | ||||
| T3 | 168 | 29 (17) | 139 (83) | 0.007 |
| T4 | 41 | 15 (37) | 26 (63) | |
| Histologic type | ||||
| Wel/Moda | 199 | 42 (21) | 157 (79) | 1.00 |
| Por/Mucb | 10 | 2 (20) | 8 (80) | |
| Lymphatic invasion | ||||
| No or minimal | 186 | 36 (19) | 150 (81) | 0.087 |
| Moderate to severe | 23 | 8 (35) | 15 (65) | |
| Venous invasion | ||||
| No or minimal | 148 | 28 (19) | 120 (81) | 0.24 |
| Moderate to severe | 61 | 16 (26) | 45 (74) | |
| Tumor buddingc | ||||
| G1/G2 | 166 | 30 (18) | 136 (82) | 0.038 |
| G3 | 43 | 14 (33) | 29 (67) | |
| Number of retrieved lymph nodes | ||||
| ≥12 | 162 | 30 (19) | 132 (81) | 0.095 |
| <12 | 47 | 14 (30) | 33 (70) | |
| Serum CEA level | ||||
| Low (≤5.0 ng/ml) | 150 | 22 (14) | 128 (86) | <0.001 |
| High (>5.0 ng/ml) | 59 | 22 (37) | 37 (63) | |
| Serum SLX level | ||||
| Low (≤38 U/ml) | 190 | 34 (18) | 156 (82) | <0.001 |
| High (>38 U/ml) | 19 | 10 (33) | 9 (67) | |
| SLX at non-invasive frontal region | ||||
| Low expression | 171 | 18 (41) | 153 (93) | <0.001 |
| High expression | 38 | 26 (59) | 12 (7) | |
a
Well to moderately differentiated tubular adenocarcinoma.
b
Poorly differentiated adenocarcinoma or mucinous carcinoma.
c
Grade of tumor budding: G1, 0–4 foci; G2, 5–9 foci; and G3, 10 or more foci (per ×200 microscopic field). SLX, Sialyl Lewisx.