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. 2018 Jan 15;19:3. doi: 10.1186/s13059-017-1384-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Graphical abstract - Wnt/beta-catenin activation affects neighbouring cells. Epidermal cells in culture adopt one of five distinct transcriptomic states differing on the basis of proliferation and commitment to differentiation. Wnt/beta-catenin signalling acts as a non-cell autonomous signalling cue to activate a handful of TFs including Smad3/4, E2f1/4 and Bcl3 in neighbours. Concurrently, transcriptional heterogeneity is reduced as neighbour cells enter into a committed and proliferative transcriptional state