Figure 1.

ICG-001 suppresses proliferation and induces growth arrest in UM cells. (A) ICG-001 suppresses the growth of a panel of UM cells. MTT assay was performed after 96 hours of ICG-001 treatment. Results shown are average ± SEM. (B) ICG-001 induces cell cycle arrest. Mel270 and Mel202 UM cells were treated with ICG-001 for 24 and 72 hours and stained with propidium iodide. Cell cycle distribution is shown as bar graphs. Experiments were repeated three times with similar results; shown here is one representative experiment performed with at least three technical replicates. Results shown are average ± SD. Representative histograms are shown in Supplementary Figure S1.