Figure 7.

ICG-001 suppresses the expression of genes associated with metastasis in vivo and its transcriptomic footprint is associated with increased patient overall survival. (A–D) GSEA of various UM clinical datasets against the transcriptomic footprint of ICG-001 in UM demonstrates that ICG-001 potently suppresses gene expression profiles associated with UM metastasis. (E) The ICG-001 gene expression profile, applied to a UM patient dataset (TCGA) shows a statistically significant association with clinical outcomes. UM patient samples exhibiting low ICG-001 signature (lower 20% of patients) had inferior overall survival.