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. 2018 Feb 26;339:140–152. doi: 10.1016/j.bbr.2017.11.030

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Food burrowing performance in htau/mtau^+/− mice is improved by NMNAT1 overexpression. The timeline of in vivo assessment is detailed in panel (A). Food-burrowing performance was assessed at two (B), three (C), four (D), five (E) and six (F) months of age. At the age of two months (B), burrowing behavior was strongly impaired in all genotypes compared to wild type control mice. However, from three- to six-months-of-age (C-F), increasing NMNAT1 levels in htau/mtau^+/− mice progressively rescued their food burrowing deficit, whilst reducing NMNAT1 levels did not further decrease their low performance. (n = 12/group, three-way ANOVA *, p < 0.05 compared to wild type mice.).