Fig. 2.

Survival of tamoxifen resistance specific markers. a. The two Gene Expression Omnibus (GEO) sets (GSE66607 and GSE37405) were overlapped and 5 miRNAs (Fig. 2a, hsa-miR-324-3p, hsa-miR-486-5p, hsa-miR-940, hsamiR-542-5p, hsa-miR-421) were obtained. b. Association of has-miR-542-5p expression with tamoxifen resistance outcome in GSE37405. Survival curves were generated using the Kaplan-Meier method and the log rank test was used to assess the statistical significance of differences. (Log Rank =0.019), Red: high expression; black: low expression. c. In the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) data set, the high expression of has-miR-542-5p was also associated with overall survival in patients with ER- positive endocrine therapy in 695 patients (logrankP = 0.00041, HR = 0.6(0.45–0.8). Red: high expression; black: low expression