Table 1.

Draize test scores after single and multiple dose formulations: saline, BH solution, blank-BMEMs, and BMEMs (n=5)

Symptom	Normal saline		Blank-BMEM		BMEM		BH solution		Normal
	Single	Multiple	Single	Multiple	Single	Multiple	Single	Multiple
Cornea	0	0	0	0	0	0	0	0	0
Iris	0	0	0	0	0	0	0	0.3	0
Conjunctiva congestion	1	0.8	0	0.2	1	1	1	1	0.2
Conjunctive edema	0	0	0	0	0	0	0	0.3	0
Secretions	0	0	0	0	0	0	0	0.3	0
Score	1	0.8	0	0.2	1	1	1	2	0.2

Abbreviations: BH, betaxolol hydrochloride; BMEM, betaxolol hydrochloride encapsulated microsphere.