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. 2018 Jan 12;13:387–402. doi: 10.2147/IJN.S146942

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© 2018 Shi et al. This work is published and licensed by Dove Medical Press Limited

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Scheme 1 — Synthetic scheme for the synthesis of the folic acid-labeled diethylaminoethyl-chitosan.

Abbreviations: CH, chitosan; DCC, dicyclohexylcarbodiimide; DEAE, diethylethylamine; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; FA, folic acid; NHS, N-hydroxysuccinimide; PEG, polyethylene glycol.