Table 1.

Arthritis and therapeutic effects in mice on day 10

Animal groups	Arthritis score (0–16)	Hind paw thickness (mm)
Group 1	0.0	1.86±0.03
Group 2	14.75±0.37	2.85a±0.11
Group 3	13.69±0.69	2.98±0.25
Group 4	10.06b±1.67	2.33b±0.25
Group 5	14.50c±0.50	3.12c±0.04

Notes: Group 1: normal control; group 2: CAIA control; group 3: DEAE₁₅-CH/siRNA-TNFα–treated mice; group 4: folate-PEG-CH-DEAE₁₅/siRNA-TNFα–treated mice; group 5: siRNA-TNFα–treated mice. The data are expressed as means ± SEM. Groups 1–4: eight mice each; group 5: five mice.

^aP<0.001 compared to normal mice.

^bP<0.05 compared to CAIA mice.

^cP<0.05 compared to group 4.

Abbreviations: CAIA, collagen antibody-induced arthritis; CH, chitosan; DEAE, diethylethylamine; PEG, polyethylene glycol; SEM, standard error of the means; TNFα, tumor necrosis factor-alpha.