Table 1.
Genotypic and allelic frequencies of VDR gene polymorphisms in H. pylori-infected and -uninfected patients from Belém, Pará, Brazil
| VDR/SNPs |
H. pylori infection
|
χ2 (p-value) | OR (CI 95%) | ORa (CI 95%) | |
|---|---|---|---|---|---|
| Positive
|
Negative
|
||||
| n=117 (%) | n=91 (%) | ||||
| FokI | |||||
| Genotypes | |||||
| FF | 56 (47.86) | 41 (45.05) | 0.2061 (0.9021) | 1.00b | 1.00b |
| Ff | 45 (38.46) | 36 (39.56) | 0.92 (0.50–1.66) | 0.81 (0.44–1.52) | |
| ff | 16 (13.68) | 14 (15.38) | 0.18 (0.37–1.90) | 1.04 (0.44–2.42) | |
| Alleles | |||||
| F | 157 (67.09) | 118 (64.84) | 0.2331 (0.6292) | 1.00b | |
| f | 77 (32.91) | 64 (35.16) | 0.90 (0.60–1.36) | ||
| BsmI | |||||
| Genotypes | |||||
| BB | 23 (19.66) | 11 (12.09) | 11.325 (0.0034) | 1.00b | 1.00b |
| Bb | 20 (17.09) | 34 (37.36) | 0.28 (0.11–0.70) | 0.29 (0.11–0.72) | |
| bb | 74 (63.25) | 46 (50.55) | 0.77 (0.34–1.72) | 0.70 (0.31–1.59) | |
| Alleles | |||||
| B | 66 (28.21) | 56 (30.77) | 0.3247 (0.5687) | 1.00b | |
| b | 168 (71.79) | 126 (69.23) | 1.13 (0.74–1.73) | ||
| ApaI | |||||
| Genotypes | |||||
| AA | 47 (40.17) | 37 (40.66) | 0.4525 (0.7974) | 1.00b | 1.00b |
| Aa | 48 (41.03) | 40 (43.96) | 0.94 (0.52–1.72) | 0.91 (0.49–1.68) | |
| aa | 22 (18.80) | 14 (15.38) | 1.24 (0.56–2.74) | 1.23 (0.53–2.83) | |
| Alleles | |||||
| A | 142 (60.68) | 114 (62.64) | 0.1650 (0.2331) | 1.00b | |
| a | 92 (39.32) | 68 (37.36) | 1.09 (0.73–1.62) | ||
| TaqI | |||||
| Genotypes | |||||
| TT | 70 (59.83) | 53 (58.24) | 0.0766 (0.9624) | 1.00b | 1.00b |
| Tt | 39 (33.33) | 32 (35.16) | 0.92 (0.51–1.66) | 0.95 (0.52–1.73) | |
| tt | 8 (6.84) | 6 (6.59) | 1.01 (0.33–3.09) | 1.00 (0.52–1.73) | |
| Alleles | |||||
| T | 179 (76.50) | 138 (75.82) | 0.0254 (0.8732) | 1.00b | |
| t | 55 (23.50) | 44 (24.18) | 0.96 (0.61–1.52) | ||
Notes:
a
Age and sex-adjusted OR.
b
1.00=reference group used in the analysis.
Abbreviations: VDR, vitamin D receptor; H. pylori, Helicobacter pylori; SNP, single nucleotide polymorphism; OR, odds ratio.