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Methylene Blue, salubrinal or guanabenz suppresses acute paralysis in ATXN3-CAG89 transgenics. The swimming activity of ATXN3-CAG89 worms was scored for a period of 10 h, and treatment with (A) 60 μM MB (**P<0.01), (B) 50 µM Sal (***P<0.001) or (C) 50 µM Gua (****P<0.0001) (by Student's unpaired t-test) significantly rescued the impaired movement phenotype of ATXN3-CAG89 worms. This experiment was done three times. Gua, guanabenz; MB, Methylene Blue; Sal, salubrinal.
