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. 2017 Dec 1;10(12):1481–1488. doi: 10.1242/dmm.031864

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Lyplal1 knockout does not alter body composition in Lyplal1 knockout mice fed high-fat diet from 6 weeks of age. (A) Body weights of mice up to 28 weeks of age were not altered by genotype. (B-D) Lean mass (B), fat mass (C) and fat percentage (D) were unaltered in 24-week-old mice, measured by DEXA. (E-G) scWAT (E), vWAT (F) and BAT (G) mass were unchanged in 28-week-old mice, weighed after dissection. (H) No qualitative change in scWAT morphology in knockout mice. Representative images are shown of scWAT sections from 28-week-old mice stained with H&E. (I) No change in adipocyte CSA was determined using ImageJ analysis of scWAT sections stained with H&E, analysed using PhenStat. (J) No change in fatty liver in knockout mice. Representative images are shown of liver sections from 28-week-old mice stained with Oil Red O and Haematoxylin. Black triangles, male Lyplal1^+/+; white triangles, male Lyplal1^tm1a/tm1a; black circles, female Lyplal1^+/+; white circles, female Lyplal1^tm1a/tm1a. Data are presented as means±s.d. Mixed model analysis was performed using PhenStat. [(B-D) n=10 male Lyplal1^+/+, n=11 male Lyplal1^tm1a/tm1a, n=9 female Lyplal1^+/+, n=8 female Lyplal1^tm1a/tm1a; (E,F) n=9 male Lyplal1^+/+, n=10 male Lyplal1^tm1a/tm1a, n=9 female Lyplal1^+/+, n=7 female Lyplal1^tm1a/tm1a; (G) n=10 male Lyplal1^+/+, n=10 male Lyplal1^tm1a/tm1a, n=9 female Lyplal1^+/+, n=8 female Lyplal1^tm1a/tm1a; (H,I) n=9 male Lyplal1^+/+, n=8 male Lyplal1^tm1a/tm1a, n=7 female Lyplal1^+/+, n=8 female Lyplal1^tm1a/tm1a]. BAT, brown adipose tissue; CSA, cross-sectional area; H&E, Haemotoxylin and Eosin; KO, knockout; scWAT, subcutaneous white adipose tissue; vWAT, visceral white adipose tissue; WT, wild type.