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. 2017 Dec 1;10(12):1481–1488. doi: 10.1242/dmm.031864

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Lyplal1 knockout does not alter glucose metabolism in mice. (A-D) Intraperitoneal insulin tolerance test (ipITT) at 18 weeks of age (A) and intraperitoneal glucose tolerance test (ipGTT) at 22 weeks of age (B) demonstrated no alteration in glucose clearance in knockout mice. (C,D) The AUC was calculated for both ipITT (C) and ipGTT (D). AUC mixed model analysis was performed using Phenstat. (E) Plasma insulin concentrations after a 4 h fast were unaltered in 28-week-old knockout mice, determined by ELISA, mixed model analysis performed using PhenStat. (F-H) Indirect calorimetry of mice at 26 weeks of age. No differences were observed in average activity count (F), RER (G) or energy expenditure (H). Black triangles, male Lyplal1^+/+; white triangles, male Lyplal1^tm1a/tm1a; black circles, female Lyplal1^+/+; white circles, female Lyplal1^tm1a/tm1a; dashed line, male Lyplal1^+/+; dotted line, male Lyplal1^tm1a/tm1a; dash-dot line, female Lyplal1^+/+; dash-dot-dot line, female Lyplal1^tm1a/tm1a. Data are presented as means±s.d., with linear regression lines as appropriate. [(A,C) n=6 male Lyplal1^+/+, n=6 male Lyplal1^tm1a/tm1a, n=6 female Lyplal1^+/+, n=5 female Lyplal1^tm1a/tm1a; (B,D) n=9 male Lyplal1^+/+, n=9 male Lyplal1^tm1a/tm1a, n=10 female Lyplal1^+/+, n=8 female Lyplal1^tm1a/tm1a; (E) n=10 male Lyplal1^+/+, n=11 male Lyplal1^tm1a/tm1a, n=9 female Lyplal1^+/+, n=8 female Lyplal1^tm1a/tm1a; (F,G) n=9 male Lyplal1^+/+, n=8 male Lyplal1^tm1a/tm1a, n=6 female Lyplal1^+/+, n=7 female Lyplal1^tm1a/tm1a; (H) n=9 male Lyplal1^+/+, n=8 male Lyplal1^tm1a/tm1a, n=6 female Lyplal1^+/+, n=6 female Lyplal1^tm1a/tm1a]. AUC, area under the curve; KO, knockout; RER, respiratory exchange ratio; WT, wild type.