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. 2017 Dec 15;144(24):4563–4572. doi: 10.1242/dev.149443

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© 2017. Published by The Company of Biologists Ltd

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Fig. 7. — Introduction of an Mfap5 knockout allele into the Fgfr3;4 mutant background attenuates alveolar simplification. (A-C) Representative H&E-stained sections from the alveolar regions of P8 Fgfr3;4 mutant and Mfap5;Fgfr3;4 mutant lungs. (D) MLI analysis indicates a statistically significant decrease in Mfap5;Fgfr3;4 lungs compared with Fgfr3;4 mutant lungs (control versus Mfap5^+/−;Fgfr3;4, ***P=0.0001; control versus Mfap5^−/−;Fgfr3;4, **P=0.006; Mfap5^+/−;Fgfr3;4 versus Mfap5^−/−;Fgfr3;4, **P=0.002; n=4 each group). (E-J) Representative immunofluorescently stained section for elastin (red) in the alveolar region of P8 and P2 normal control, Fgfr3;4 mutant and Mfap5;Fgfr3;4 lungs. There is rescue to longer and more organized elastin fibers in Mfap5;Fgfr3;4 compared with Fgfr3;4 mutant lungs. Scale bars: 100 μm.