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. 2017 Nov 3;6(12):1861–1868. doi: 10.1242/bio.026963

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Activation of non-canonical wnt signalling rescues fzd7 CRD-induced cardia bifida. (A,Ai) Wild-type control embryos showing normal tnnic expression in the heart. (B,Bi) fzd7 full-length (fzd7 FL) overexpression (500 pg) injected into the dorsal blastomeres (DB) at the 4-cell stage show normal heart expression of tnnic despite suffering a severe extension movement defect. (C) Embryos injected with 500 pg fzd7 CRD show cardia bifida phenotype, note that embryos have normal to mild convergent extension defects. (D) Rescue of the fzd7 CRD (250 pg) cardia bifida phenotype with 250 pg fzd7 FL, embryos show normal morphology as well as normal tnnic expression. (F) Graph of fzd7 CRD cardia bifida phenotype rescue with fzd7 FL. (E,Ei) Rescue of fzd7 CRD (500 pg) cardia bifida phenotype with dishevelled1-Delta-N (Dvl1ΔN, 1.25 ng) indicating that fzd7 is required for the non-canonical signalling in the heart. (G) Graph of fzd7 CRD cardia bifida phenotype rescue with dvl1ΔN, panel Gi is the key for the cardia bifida phenotype scoring in G. Magnification 20×.