Table 1.

Recommendations.

Models	Treatment timing	Outcome measures	Assessment timing
CPSP	• Preoperative • Peri-operative • Duration of acute pain recovery (based on natural history of recovery for each surgery)	• Presence vs. absence of pain • Presence vs. absence of “clinically meaningful” pain • Pain intensity at rest • Pain intensity upon movement and specific activities (well defined) • Pain qualities Secondary endpoints: physical and emotional functioning	• 24-48 hours post-surgery • 3, 6, and 12 months • Surgery-specific times based on natural history of acute to chronic pain transition
PHN	• As soon as possible after rash onset (but ≤ 7 days) • Duration of acute HZ pain (≤ 30 days from rash onset)	• Presence vs. absence of pain in the area of the rash • Presence vs. absence of “clinically meaningful” pain in the area of the rash • Pain intensity at HZ rash location • Pain qualities at HZ rash location Secondary endpoints: physical and emotional functioning	• 3-4 months after rash onset
CLBP	• As soon as possible after an acute back pain episode (within 3 weeks) • Duration of acute pain (~ 3 months)	• Presence vs. absence of chronic pain as defined by NIH Task Force [37] • Pain intensity • AUC of pain assessments between 3 months and final time point Secondary endpoints: physical and emotional functioning	• 3, 6, and 12 months
Painful CIPN	• Pre-chemotherapy • Duration of chemotherapy (either daily or only proximal to chemotherapy infusions)	• Presence vs. absence of pain • Presence vs. absence of “clinically meaningful” pain Secondary endpoints: physical and emotional functioning	• 3 and 6 months

Chronic post-surgical pain (CPSP), postherpetic neuralgia (PHN), herpes zoster (HZ), chronic low back pain (CLBP), chemotherapy-induced peripheral neuropathy (CIPN), area under the curve (AUC)