Figure 1.

Nup98 binds to transcription start sites adjacent to regions of H3K4me3 in mouse HPCs. (A) ChIP-seq trace showing a characteristic peak for Nup98 binding (top) and H3K4me3 binding (bottom) to an example gene, Sec23a. (B) Correlation between H3K4me3 binding and Nup98 binding near transcription start sites. H3K4me3 data were derived from previously published data (Bernt et al. 2011). (C) Pie chart showing the percentage of peaks found in a particular region of the genome for Nup98, Runx1 (Wu et al. 2012), and HOXB4 (Fan et al. 2012) ChIP-seq data sets. (D) GO analysis results for genes whose promoters were bound by Nup98. Gene clusters and P-values were identified using DAVID open access software. Gene clusters that were found to be among the most highly expressed in HPCs are highlighted in red.