Fig. 2.

Expression of C3 and C5 complement proteins by mouse and human pancreas. A–D Co-localisation of C3 (A, B) and C5 (C, D) complement proteins (green) with the islet hormones insulin (a–c), glucagon (d–f) and somatostatin (g–i) (red) in mouse (A, C) and human (B, D) islets. Nuclei have been counterstained with DAPI (blue). C3 and C5 were also expressed by exocrine cells in both mouse and human pancreas. E, G C3 co-localises in mouse and human islets with insulin, glucagon and somatostatin, indicating expression of C3 in β-, α- and δ-cells. F, H C5 co-localises in mouse and human islets primarily with insulin, indicating predominant expression of C5 in β-cells