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Stimulatory effects of C3aR and C5aR1 agonists on intracellular calcium in mouse islets. C3aR (1 µM, sc-214644) and C5aR1 (1 µM, 65121-ANA) agonists reversibly elevated [Ca2+]i in mouse islet cells. 500 µM carbachol was used as a positive control. Mean changes in [Ca2+]i levels in six individual cells, expressed as the 340 nm/380 nm fluorescence ratio, are shown in black and the SEMs for each time point are shown in grey
