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Effects of C3aR and C5aR1 agonists on mouse and human islet apoptosis. Caspase 3/7 activities in mouse (a, b) and human (c, d) islets were induced by a cocktail of pro-apoptotic cytokines (a, c) or by palmitate (b, d). sc-214644 and 65121-ANA protected against apoptosis in both mouse and human islets. 20 nM Exendin-4 was included as reference treatment for the human islet experiments (c, d). ***p < 0.001, n = 6
