Fig. 2.

Klk7 deficiency in adipose tissue causes a redistribution of adipose tissue from epigonadal to subcutaneous AT depots under high fat diet conditions independently of total body fat mass gain. a, b Body weight gain and c final body weight of ATKlk7 ^−/− and control littermates fed a regular chow diet for 26 weeks (a) or a 55% high fat diet (HFD) for 14 weeks (b), starting at the age of 6 weeks (n = 9–16). d, e The percentage of fat mass and lean body mass as determined by EchoMRI at the end of the studies under chow (at age 26 weeks) and HFD conditions (20 weeks of age; n = 10–12). f–h Relative organ weights of liver, epigonadal and subcutaneous white adipose tissue depots (n = 8–14) at the end of chow and HFD studies. ATKlk7 ^−/− exhibits altered fat distribution with increased subcutaneous and decreased epigonadal AT mass. Data are represented as mean ± SEM and for each diet condition differences between genotypes were tested for statistical significance by a two-tailed Student’s t test; *P < 0.05, **P < 0.01, ***P < 0.001