Table 4.

Safety and effectiveness of chemoradiotherapy using 5-fluorouracil plus mitomycin C to treat anal squamous cell carcinoma

Reference	Study type	Number of patients	RT technique used	Median follow-up time (mo)	Local control	Overall survival	Acute toxicity (%)
							Hematological grade	Dermatological ≥ grade 3	Gastrointestinal ≥ grade 3	Genitourinary ≥ grade 3	Pain ≥ grade 3
RTOG 9811 [1,10]	Phase III	325	Conventional technique	ND	20% at 5 yearsa)	78.3% at 5 years	26	48	35	3	24
Satake et al. [15]	Retrospective	7	Conventional technique	37.5	83.3% at 3 yearsb)	100% at 3 years	14	100	0	0	71
Kachnic et al. [21]	Retrospective	43	SIB-IMRT	24	95% at 2 yearsc)	94% at 2 years	12	10	7	7	ND
RTOG 0529 [5]	Phase II	52	SIB-IMRT	ND	ND	ND	27	23	21	2	23
Call et al. [19]	Retrospective	34	SIB-IMRT	22	90% at 2 yearsc)	93% at 2 years	32	15	9	ND	ND
This study	Retrospective	10	SIB-IMRT	46	88.9% at 3 yearsd)	100% at 3 years	50	10	20	0	20

RT, radiotherapy; ND, not described; SIB-IMRT, simultaneous integrated boost intensity-modulated radiotherapy.

^a)Locoregional failure rate.

^b)Disease-free survival rate.

^c)Local control rate.

^d)Locoregional control rate.