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. Author manuscript; available in PMC: 2018 Jan 16.
Published in final edited form as: Clin Cancer Res. 2016 Dec 30;23(12):3109–3119. doi: 10.1158/1078-0432.CCR-16-1508

Figure 2. Bone marrow-derived cells (BMDCs) are recruited to the tumor microenvironment.

Figure 2

(A) Representative photomicrographs of tumor cross sections from GFP+ bone marrow transplanted mice counterstained with CD31+ at low- (n=4) and high-grade stages (n=4)(4 and 8 weeks, respectively), Scale bar 50μm. (B) Representative flow cytometric analysis of brain tumor tissue from RCAS murine animals gated for GFP+ cells in low (n=4) and high grade tumors (n=4), * p<0.05. (C) Confocal microscopic analysis of high grade tumor sections (n=3 animals, >6 sections/tumor) stained for DAPI and CD11b from GFP+ bone marrow transplanted RCAS mice, Scale bar 50μm(D) Quantification of cells labeled with GFP+, CD11b+, and co-stained (GFP+/CD11b+). Percentage of CD11b+/GFP+ cells.