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. Author manuscript; available in PMC: 2018 Jan 16.
Published in final edited form as: Nat Cell Biol. 2015 May 18;17(6):816–826. doi: 10.1038/ncb3169

Figure 3. Pancreatic ductal adenocarcinoma-derived exosomes induce fibronectin expression and migration of bone marrow-derived cells to the liver.

Figure 3

(a) Immunofluorescence quantification of FN expression in arbitrary units (A.U.) and F4/80+ cell frequency in the livers of mice during the course of PAN02 exosome education; n = 4 mice from one experiment. **P < 0.01, ***P < 0.001 by ANOVA relative to control (day 0). Scale bars, 100μm. (b) Immunofluorescence quantification of the frequency of bone marrow (BM)-derived F4/80+ (upper) and Gr1+ (lower) cells in the liver following transplantation of GFP+ BM from mice educated with PBS (CTL) or PAN02 exosomes (Exo); n = 4 (F4/80) and n = 3 (Gr1) mice from one experiment. **P < 0.01, *P < 0.05 by two-tailed t-test. Scale bars, 50μm. All statistical source data are presented in Supplementary Table 4. All data are represented as mean±s.e.m.