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. 2017 Oct-Dec;11(4):364–370. doi: 10.1590/1980-57642016dn11-040005

Table 1. Rules for the pathological diagnosis of AD.

• The NIA criteria for assessing plaques (including diffuse and neuritic plaques) in the neocortex and hippocampus per unit and corrected by age.
• The criteria based on the semi-quantitative evaluation of plaques and neurofibrillary tangle in the neocortex and hippocampus.
• The CERAD criteria using the semi-quantitative neuritic plaques count adjusted by age, which along with the clinical history of dementia is used to set up the probability of AD.
• The topographic categorization of neuritic (neurofibrillary) changes, which includes 6 stages: entorhinal (1 and 2), hippocampal (3 and 4), and neocortical (5 and 6).
• The quantitative criteria of the University of Washington, which is a NIA criteria modification.