Table 1. Rules for the pathological diagnosis of AD.
• The NIA criteria for assessing plaques (including diffuse and neuritic plaques) in the neocortex and hippocampus per unit and corrected by age. |
• The criteria based on the semi-quantitative evaluation of plaques and neurofibrillary tangle in the neocortex and hippocampus. |
• The CERAD criteria using the semi-quantitative neuritic plaques count adjusted by age, which along with the clinical history of dementia is used to set up the probability of AD. |
• The topographic categorization of neuritic (neurofibrillary) changes, which includes 6 stages: entorhinal (1 and 2), hippocampal (3 and 4), and neocortical (5 and 6). |
• The quantitative criteria of the University of Washington, which is a NIA criteria modification. |